Sorin Lab News

Spring 2017

news photo Sorin Lab alumnus/B.S. Biochemistry graduate Dakota Rochelle begins his dental training this fall in the D.D.S. program @ UCSF

news photo Recent Biochem/Physics graduate Yessica Gomez received the 2017 Hypercube Award and begins her Ph.D. in Biophysics this fall @ UCSF

news photo M.S. Computer Science major Vardo Barsegyan earned an Engineering Alumni Scholarship and a CSULB Summer Research Award


Spring/Fall 2016

news photo M.S. Physics major Walter Alvorado presented his work on enzyme-drug binding at the 2016 Physical Society Far West Conference @ UC Davis

news photo Sorin Lab alumus Amethyst Radcliffe was recently featured in the APS Newsletter for her work on thin films at PPG Aerospace

news photo Sorin Lab System Administrator/Computer Science major Xavier Martinez was recently inducted into the RISE program

news photo Lab alumnus Analisa Garcia has completed her Undergraduate Honors Thesis and is heading for USC Pharmacy School in Fall 2016

news photo Sorin Lab researcher and B.S. Chemical Engineering major Angela Choy received a 2016 Boeing Academic Scholarship


news photo Biochemistry major Sean McCoy graduated with Department Honors and received the AIC Biochemist of the Year award

news photo Biochemistry/Physics double major Yessica Gomez was awarded a 2016 Women & Philanthropy Research Scholarship


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Computational Biochemistry & Biophysics

Members of the Sorin Lab study the structure and dynamics of biological molecules via computer modeling and simulation. Using cluster computing and the Folding@Home Distributed Computing Project, we can apply a variety of models and methods to sample large numbers of independent simulations: we are now capable of simulating some molecular events in dynamic equilibrium, making simulation a powerful tool with which to probe topics in molecular biology and biophysics including molecular recognition and drug design, RNA and protein folding, and related processes.
[ Click here to apply for a position in the Sorin Lab (.doc application) ]


Sorin Lab June 2012

From left to right: Aingty Eung, Yessica Gomez, Xavier Martinez, Omega Nnoham, Prof. Eric J. Sorin, Kim Padron, Vardo Barsegyan, Mariel Sanchez, Walter Alvarado, Nick Humphrey, and Angela Choy.


Recent Publications

Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors
Kensaku Nakayamaa*, Jason P. Schwans*, Eric J. Sorin*, Trina Tran, Jeannette Gonzalez, Elvis Arteaga, Sean McCoy & Walter Alvarado (2017). Bioorganic & Medicinal Chemistry, 25(12), 3171–3181, doi:10.1016/j.bmc.2017.04.002.
ApoE
Ensemble simulations: folding, unfolding and misfolding of a high-efficiency frameshifting RNA pseudoknot Khai K. Q. Nguyen, Yessica K. Gomez, Mona Bakhom, Amethyst Radcliffe, Phuc La, Dakota Rochelle, Ji Won Lee & Eric J. Sorin* (2017). Nucleic Acids Research 45, doi:10.1093/nar/gkx012.
ApoE
Ensemble Molecular Dynamics of a Protein-Ligand Complex: Residual Inhibitor Entropy Enhances Drug Potency in Butyrylcholinesterase Eric J Sorin*, Walter Alvarado, Samantha Cao, Amethyst Radcliffe, Phuc La & Yi An (2017). Bioenergetics 6(1), DOI:10.4172/2167-7662.1000145.
ApoE
The Extent of Pyrene Excimer Fluorescence Emission Is a Reflector of Distance and Flexibility: Analysis of the Segment Linking the LDL Receptor-Binding and Tetramerization Domains of Apolipoprotein E3 Gursharan K. Bains, Sea H. Kim, Eric J. Sorin, & Vasanthy Narayanaswami* (2012). Biochemistry 51, 6207-6219.
gnra
Equilibrium Conformational Dynamics in an RNA Tetraloop from Massively Parallel Molecular Dynamics Allison J. DePaul, Erik J. Thompson, Sarav S. Patel, Kristin Haldeman, & Eric J. Sorin* (2010). Nucleic Acids Research. 38, 4856-4867.