Sorin Lab News
Spring 2017
Sorin Lab alumnus/B.S. Biochemistry graduate Dakota Rochelle begins his dental training this fall in the D.D.S. program @ UCSF
Recent Biochem/Physics graduate Yessica Gomez received the 2017 Hypercube Award and begins her Ph.D. in Biophysics this fall @ UCSF
M.S. Computer Science major Vardo Barsegyan earned an Engineering Alumni Scholarship and a CSULB Summer Research Award
Spring/Fall 2016
M.S. Physics major Walter Alvorado presented his work on enzyme-drug binding at the 2016 Physical Society Far West Conference @ UC Davis
Sorin Lab alumus Amethyst Radcliffe was recently featured in the
APS Newsletter for her work on thin films
at PPG Aerospace
Sorin Lab System Administrator/Computer Science major Xavier Martinez was recently inducted into the RISE program
Lab alumnus Analisa Garcia has completed her Undergraduate Honors Thesis and is heading for USC Pharmacy School in Fall 2016
Sorin Lab researcher and B.S. Chemical Engineering major Angela Choy received a 2016 Boeing Academic Scholarship
Biochemistry major Sean McCoy graduated with Department Honors and received the AIC Biochemist of the Year award
Biochemistry/Physics double major Yessica Gomez was awarded a 2016 Women & Philanthropy Research Scholarship
[ Click here to visit our news archive ]
Computational Biochemistry & Biophysics
Members of the Sorin Lab study the structure and dynamics of biological molecules via computer modeling and simulation.
Using cluster computing and the Folding@Home Distributed Computing Project, we can apply a variety of models and
methods to sample large numbers of independent simulations: we are now capable of simulating some molecular events
in dynamic equilibrium, making simulation a powerful tool with which to probe topics in molecular biology and biophysics
including molecular recognition and drug design, RNA and protein folding, and related processes.
[ Click here to apply for a position in the Sorin Lab (.doc application) ]
Recent Publications
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Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates,
effective butyrylcholinesterase inhibitors Kensaku Nakayamaa*, Jason P. Schwans*, Eric J. Sorin*, Trina Tran, Jeannette Gonzalez, Elvis Arteaga, Sean McCoy & Walter Alvarado (2017). Bioorganic & Medicinal Chemistry, 25(12), 3171–3181, doi:10.1016/j.bmc.2017.04.002. |
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Ensemble simulations: folding, unfolding and misfolding of a high-efficiency frameshifting RNA pseudoknot Khai K. Q. Nguyen, Yessica K. Gomez, Mona Bakhom, Amethyst Radcliffe, Phuc La, Dakota Rochelle, Ji Won Lee & Eric J. Sorin* (2017). Nucleic Acids Research 45, doi:10.1093/nar/gkx012. |
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Ensemble Molecular Dynamics of a Protein-Ligand Complex: Residual Inhibitor Entropy Enhances Drug Potency in Butyrylcholinesterase
Eric J Sorin*, Walter Alvarado, Samantha Cao, Amethyst Radcliffe, Phuc La & Yi An
(2017). Bioenergetics 6(1), DOI:10.4172/2167-7662.1000145.
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The Extent of Pyrene Excimer Fluorescence Emission Is a Reflector of
Distance and Flexibility: Analysis of the Segment Linking the LDL Receptor-Binding and Tetramerization Domains of Apolipoprotein E3
Gursharan K. Bains, Sea H. Kim, Eric J. Sorin, & Vasanthy Narayanaswami* (2012). Biochemistry 51, 6207-6219.
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Equilibrium Conformational Dynamics in an RNA Tetraloop
from Massively Parallel Molecular Dynamics
Allison J. DePaul, Erik J. Thompson, Sarav S. Patel, Kristin Haldeman, & Eric J. Sorin* (2010). Nucleic Acids Research.
38, 4856-4867.
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