Sorin Lab News

Fall 2016

news photo Sorin Lab alumus Amethyst Radcliffe was recently featured in the APS Newsletter for her work on thin films at PPG Aerospace

Spring 2016

news photo Sorin Lab System Administrator/Computer Science major Xavier Martinez was recently inducted into the RISE program

news photo Lab alumnus Analisa Garcia has completed her Undergraduate Honors Thesis and is heading for USC Pharmacy School in Fall 2016

news photo Sorin Lab researcher and Chemical Engineering major Angela Choy received a 2016 Boeing Academic Scholarship

news photo Biochemistry/Physics double major Yessica Gomez was awarded a 2016 Women & Philanthropy Research Scholarship

news photo Biochemistry major Sean McCoy graduated with Department Honors and received the AIC Biochemist of the Year award

Fall 2015

news photo MS Physics major Walter Alvarado won Best Graduate Student Poster at the 2015 Far West meeting of the American Physical Society

Spring 2015

news photo Biochem major Ji Won Lee graduated with Dept Honors and received the 2015 AIC Biochemist of the Year award

news photo Sorin Lab biochemistry major Khai Nguyen was awarded the 2015 Hypercube Award for computational chemistry

news photo Biochemistry major Dakota Rochelle received a 2015 Women & Philanthropy Scholarship to support his research in RNA folding

[ Click here to visit our news archive ]

Computational Biochemistry & Biophysics

Members of the Sorin Lab study the structure and dynamics of biological molecules via computer modeling and simulation. Using cluster computing and the Folding@Home Distributed Computing Project, we can apply a variety of models and methods to sample large numbers of independent simulations. Indeed, we are now capable of simulating some molecular events in dynamic equilibrium, making simulation a powerful tool with which to probe topics in molecular biology and biophysics, including molecular recognition and drug design, RNA and protein folding, and many other processes.

Sorin Lab June 2012

From left to right: Aingty Eung, Yessica Gomez, Xavier Martinez, Omega Nnoham, Prof. Eric J. Sorin, Kim Padron, Vardo Barsegyan, Mariel Sanchez, Walter Alvarado, Nick Humphrey, and Angela Choy.

Recent Publications

Ensemble simulations: folding, unfolding and misfolding of a high-efficiency frameshifting RNA pseudoknot
Khai K. Q. Nguyen*, Yessica K. Gomez*, Mona Bakhom, Amethyst Radcliffe, Phuc La, Dakota Rochelle, Ji Won Lee & Eric J. Sorin (2017). Nucleic Acids Research 45, doi:10.1093/nar/gkx012.

Ensemble Molecular Dynamics of a Protein-Ligand Complex: Residual Inhibitor Entropy Enhances Drug Potency in Butyrylcholinesterase
Eric J Sorin, Walter Alvarado, Samantha Cao, Amethyst Radcliffe, Phuc La & Yi An (2017). Bioenergetics 6(1), DOI:10.4172/2167-7662.1000145.

The Extent of Pyrene Excimer Fluorescence Emission Is a Reflector of Distance and Flexibility: Analysis of the Segment Linking the LDL Receptor-Binding and Tetramerization Domains of Apolipoprotein E3
Gursharan K. Bains, Sea H. Kim, Eric J. Sorin, & Vasanthy Narayanaswami (2012). Biochemistry 51, 6207-6219.

Equilibrium Conformational Dynamics in an RNA Tetraloop from Massively Parallel Molecular Dynamics
Allison J. DePaul*, Erik J. Thompson*, Sarav S. Patel*, Kristin Haldeman*, & Eric J. Sorin (2010). Nucleic Acids Research. 38, 4856-4867.

Evaluating molecular mechanical potentials for helical peptides and proteins
Erik J. Thompson*, Allison J. DePaul*, Sarav Patel*, & Eric J. Sorin (2010). PLoS One, 5, e10056, doi:10.1371/journal.pone.0010056.